Nandakumar, B.; Verma, A. K.; Yu, Y.; Marshall, E.; DeNicola, A.; Wang, J.; MacKinnon, C. D.; Howell, M. J.; Vitek, J. L.; Johnson, L. A.

Sleep-associated downscaling of neuronal firing, i.e. firing rate homeostasis (FRH), is essential for restorative sleep. Sleep dysfunction is common in Parkinson\'s disease (PD), but FRH has not been investigated. Here, using a within-subject design in the nonhuman primate model of PD, we report that thalamocortical FRH is disrupted in parkinsonism. These findings can inform therapeutic approaches tailored towards normalizing FRH to reestablish restorative sleep in PD.