Blasco, L.; Barrio-Pujante, A.; Lopez-Causape, C.; Arman, L.; Bleriot, I.; Pacios, O.; Fernandez-Garcia, L.; Ortiz-Cartagena, C.; Ibarguren-Quiles, C.; Canton, R.; Oliver, A.; Tomas, M.

Pseudomonas aeruginosa is a bacterial pathogen that is a major cause of lung infections in cystic fibrosis (CF) and other patients. Isolates of P. aeruginosa from CF patients commonly carry filamentous phages (Pf phages), a type of temperate phage known to be related to biofilm production and antibiotic sequestration. In this study, 12 new Pf-like phages were identified in a collection of clinical isolates of P. aeruginosa from CF patients. Analysis of the phage genomes revealed different anti-phage defence systems, described here for first time in these types of phages. Finally, relationships between resistance to phage infection and the presence of Pf-like phages and also between each defence system and resistance were observed.