Bioinformatics

Computational Design and Atomistic Validation of a High-Affinity VHH Nanobody Targeting the PI/RuvC Interface of Streptococcus pyogenes Cas9: A Bivalent Hub Strategy for CRISPR-Cas9 Enhancement

Computational Design and Atomistic Validation ...

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librarian
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AI-guided design of candidate BMPR1A-binding peptides for cartilage regeneration: a multi-tool computational benchmarking study

AI-guided design of candidate BMPR1A-binding p...

Bioinformatics
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librarian
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STRmie-HD enables interruption-aware HTT repeat genotyping and somatic mosaicism profiling across sequencing platforms

STRmie-HD enables interruption-aware HTT repea...

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Alessandro Napoli
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From SNPs to Pathways: A genome-wide benchmark of annotation discrepancies and their impact on protein- and pathway-level inference

From SNPs to Pathways: A genome-wide benchmark...

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librarian
3 views
dreampy: Pseudobulk mixed-model differential expression for single-cell RNA-seq in Python

dreampy: Pseudobulk mixed-model differential e...

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librarian
3 views
PACMON: Pathway-guided Multi-Omics data integration for interpreting large-scale perturbation screens

PACMON: Pathway-guided Multi-Omics data integr...

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Florian Buettner
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MiCBuS: Marker Gene Mining for Unknown Cell Types Using Bulk and Single Cell RNA-Seq Data

MiCBuS: Marker Gene Mining for Unknown Cell Ty...

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Shanshan Zhang
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Col-Ovo: Smartphone-based artificial intelligence for rapid counting of Aedes mosquito eggs under field conditions

Col-Ovo: Smartphone-based artificial intellige...

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Diego Montenegro
3 views
A comprehensive reference database to support untargeted metabolomics in Pseuudomonas putida

A comprehensive reference database to support ...

Bioinformatics
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Jessica Bade
3 views
VPF-Class 2.0: a taxonomy-centered framework for automatic viral classification

VPF-Class 2.0: a taxonomy-centered framework f...

Bioinformatics
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librarian
5 views
Single-cell Landscape of T Cell Heterogeneity in Kawasaki Disease: STAT3/JAK Axis Regulates the Lineage Differentiation Bias of Th17 Cells

Single-cell Landscape of T Cell Heterogeneity ...

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Sirui Song
5 views
TogoMCP: Natural Language Querying of Life-Science Knowledge Graphs via Schema-Guided LLMs and the Model Context Protocol

TogoMCP: Natural Language Querying of Life-Sci...

Bioinformatics
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librarian
6 views
Rastair: an integrated variant and methylation caller

Rastair: an integrated variant and methylation...

Bioinformatics
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Benjamin Schuster-Boeckler
6 views
The Risk of Gulf Birds Functional Diversity Loss with Climate Change Uncovered Using Deep Learning Population Models

The Risk of Gulf Birds Functional Diversity Lo...

Bioinformatics
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Liying Li
5 views
EvoMut: A Computational Framework for Engineering Oxidative Stability in Proteins

EvoMut: A Computational Framework for Engineer...

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Seyed Shahriar Arab
4 views
Solving the Diagnostic Odyssey with Synthetic Phenotype Data

Solving the Diagnostic Odyssey with Synthetic ...

Bioinformatics
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Gianlucca Colangelo
4 views
A harmonized benchmarking framework for implementation-aware evaluation of 46 polygenic risk score tools across binary and continuous phenotypes

A harmonized benchmarking framework for implem...

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librarian
3 views
Helicase: Vectorized parsing and bitpacking of genomic sequences

Helicase: Vectorized parsing and bitpacking of...

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librarian
9 views
Long-read metagenomic sequencing reveals novel lineages and functional diversity in urban soil microbiome

Long-read metagenomic sequencing reveals novel...

Bioinformatics
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librarian
8 views
PanXpress: Gene expression quantification with a pan-transcriptomic gapped k-mer index

PanXpress: Gene expression quantification with...

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librarian
20 views
Improving genomic language model reliability under distribution shift

Improving genomic language model reliability u...

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Gavin Hearne
14 views
Differentiable Gene Set Enrichment Analysis for Pathway-Level Supervision in Transcriptomic Learning

Differentiable Gene Set Enrichment Analysis fo...

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librarian
16 views
Disagreement among variant effect predictors guides experimental prioritization of target proteins

Disagreement among variant effect predictors g...

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librarian
11 views
Mapping spatial cell-cell communication programs by tailoring chains of cells for transformer neural networks

Mapping spatial cell-cell communication progra...

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Niklas Brunn
12 views
RNASTOP: A Deep Learning Framework for mRNA Chemical Stability Prediction and Optimization

RNASTOP: A Deep Learning Framework for mRNA Ch...

Bioinformatics
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librarian
24 views
Computational Prediction of Plasmodium falciparum Antigen-T-cell Receptor Interactions via Molecular Docking: Implications for Malaria Vaccine Design

Computational Prediction of Plasmodium falcipa...

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Gilbert Kipkoech
15 views
RNAGAN: Train One and Get Four, Multipurpose Human RNA-Seq Analysis Tool with Enhanced Interpretability and Small Data Size Capability

RNAGAN: Train One and Get Four, Multipurpose H...

Bioinformatics
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librarian
12 views
ECHO: a nanopore sequencing-based workflow for (epi)genetic profiling of the human repeatome

ECHO: a nanopore sequencing-based workflow for...

Bioinformatics
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librarian
19 views
TriGraphQA: a triple graph learning framework for model quality assessment of protein complexes

TriGraphQA: a triple graph learning framework ...

Bioinformatics
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Kailong Zhao
22 views
Enhancing non-local interaction modeling for ab initio biomolecular calculations and simulations with ViSNet-PIMA

Enhancing non-local interaction modeling for a...

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librarian
13 views
GenBio-PathFM: A State-of-the-Art Foundation Model for Histopathology

GenBio-PathFM: A State-of-the-Art Foundation M...

Bioinformatics
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librarian
12 views
Pareto optimization of masked superstrings improves compression of pan-genome k-mer sets

Pareto optimization of masked superstrings imp...

Bioinformatics
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librarian
11 views
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