Cancer Biology

p53 restoration suppresses retrotransposon-driven chromosomal instability through nonlinear let-7 feedback and stochastic burst control

p53 restoration suppresses retrotransposon-dri...

Cancer Biology
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L. Boominathan
89 views
Ovarian cancer-on-chip for patient-specific profiling of treatment responses to sequential chemotherapy and PD-L1 blockade

Ovarian cancer-on-chip for patient-specific pr...

Cancer Biology
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librarian
210 views
A transcriptional signature of LKB1 functional loss defines a large, therapeutically addressable patient population across human cancers

A transcriptional signature of LKB1 functional...

Cancer Biology
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librarian
152 views
Intratumoral dose heterogeneity promotes adaptive anti-tumor immunity and predicts clinical response to radiopharmaceutical therapy

Intratumoral dose heterogeneity promotes adapt...

Cancer Biology
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librarian
143 views
Routine FFPE sections support clinically compatible single-nucleus transcriptomics across six human cancer types

Routine FFPE sections support clinically compa...

Cancer Biology
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librarian
144 views
A dual-layer computational framework for prioritising therapeutic candidates targeting extracellular vesicle-mediated immune escape in pancreatic ductal adenocarcinoma

A dual-layer computational framework for prior...

Cancer Biology
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Xiaoying Zhang
153 views
Pulsed priming with the FAK inhibitor narmafotinib enhances both gemcitabine/Abraxane and FOLFIRINOX chemotherapy response in pancreatic cancer

Pulsed priming with the FAK inhibitor narmafot...

Cancer Biology
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Paul Timpson
148 views
Macrophage-instructed GSDME couples glioblastoma cell-state plasticity with inflammatory cell death

Macrophage-instructed GSDME couples glioblasto...

Cancer Biology
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librarian
171 views
An Integrated Preclinical Platform for Lethal Neuroendocrine Prostate Cancer from Rapid Autopsy Bone and Liver Metastases.

An Integrated Preclinical Platform for Lethal ...

Cancer Biology
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Grinu Mathew
156 views
An immune-stimulating antibody conjugate spatiotemporally targeting CD47 and TLR9 elicits macrophage-dependent tumor clearance and durable anti-cancer adaptive immunity

An immune-stimulating antibody conjugate spati...

Cancer Biology
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Jung Suk
158 views
Genetic and Pharmacologic Targeting of Eya3 in Macrophages Drives Anti-Tumor Immunity in Triple-Negative Breast Cancer

Genetic and Pharmacologic Targeting of Eya3 in...

Cancer Biology
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librarian
168 views
A Novel Syngeneic Mouse Model to Study Immune Evasion in Head and Neck Squamous Cell Carcinoma

A Novel Syngeneic Mouse Model to Study Immune ...

Cancer Biology
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librarian
154 views
Ribonucleotide Reductase Inhibition Overcomes FLT3 Inhibitor Resistance in Acute Myeloid Leukemia

Ribonucleotide Reductase Inhibition Overcomes ...

Cancer Biology
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librarian
161 views
Circulating Immune Profiling Reveals Immune Signatures Associated with Disease Stage and Outcome in Endometrial Cancer

Circulating Immune Profiling Reveals Immune Si...

Cancer Biology
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librarian
145 views
iPSC-Derived Microglia-like Cells Exhibit Protocol-Dependent Transcriptomic Features and Robust Phagocytosis of Glioma Cells

iPSC-Derived Microglia-like Cells Exhibit Prot...

Cancer Biology
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librarian
143 views
Topical Activatable Fluorescence Probes for Rapid Intraoperative Detection of Peritoneal Dissemination in High-Grade Serous Ovarian Carcinoma

Topical Activatable Fluorescence Probes for Ra...

Cancer Biology
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librarian
155 views
Whole transcriptome analysis reveals ELK3 as a key driver of metastasis through regulation of 3D migration and stemness in triple-negative breast cancer cells

Whole transcriptome analysis reveals ELK3 as a...

Cancer Biology
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Daniel Cruceriu
149 views
IL-32 is a stress-responsive node locked in a noncanonical NF-κB inflammatory loop during MASLD to HCC transition

IL-32 is a stress-responsive node locked in a ...

Cancer Biology
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Jesper Andersen
158 views
Enterococcus faecalis is involved in the progression of the early stages of latent chronic pancreatitis surrounding pancreatic cancer tissue

Enterococcus faecalis is involved in the progr...

Cancer Biology
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librarian
151 views
Distinct Effects of the Extracellular Matrix on Tumor Organization and Response to Cancer Virotherapy

Distinct Effects of the Extracellular Matrix o...

Cancer Biology
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librarian
157 views
Mapping Functional Tumor Suppressor Networks in Esophageal Adenocarcinoma Using In Vivo CRISPR Screening and Perturb-sequencing

Mapping Functional Tumor Suppressor Networks i...

Cancer Biology
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Nicholas Clemons
156 views
A Pan-Cancer Multi-Omic Analysis of Copy Number Signature Clusters and Genomic Instability

A Pan-Cancer Multi-Omic Analysis of Copy Numbe...

Cancer Biology
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librarian
146 views
Chemokine-Dependent Natural Killer Cells Prevent Pulmonary Metastasis in a Newly Established Mouse Osteosarcoma Model

Chemokine-Dependent Natural Killer Cells Preve...

Cancer Biology
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librarian
161 views
Inactivation of HIF-P4H-1 Stabilizes IKKα, Modulates Non-Canonical NF-κB Signaling, and Sensitizes Cancer Cells to Cell Death

Inactivation of HIF-P4H-1 Stabilizes IKKα, Mod...

Cancer Biology
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librarian
154 views
Antibody-drug conjugate combination therapy targeting LGR5 and MET with different payloads enhances efficacy in preclinical colorectal cancer models

Antibody-drug conjugate combination therapy ta...

Cancer Biology
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librarian
158 views
METTL3 modulates cell viability and motility in HCC1143 and MDA-MB-231 triple-negative breast cancer cells

METTL3 modulates cell viability and motility i...

Cancer Biology
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Buket Sağlam-Şen
152 views
A first-in-class multimodal organomercury compound demonstrates preferential blast reduction with hematopoietic and immune restoration in Acute Lymphoblastic Leukemia

A first-in-class multimodal organomercury comp...

Cancer Biology
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librarian
154 views
PARP1 inhibition regulates tumor progression through modulation of RhoGDIα and vimentin in triple negative breast cancer

PARP1 inhibition regulates tumor progression t...

Cancer Biology
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librarian
169 views
Septins promote breast cancer cell invasion in 3D collagen gels by influencing actin-based protrusion formation

Septins promote breast cancer cell invasion in...

Cancer Biology
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librarian
139 views
R-Ras coordinates reciprocal activation of ERK5 and ERK1/2 under single pathway inhibition in melanoma

R-Ras coordinates reciprocal activation of ERK...

Cancer Biology
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librarian
144 views
E-HAPLOS: Electrical Impedance Human-guided Assesment with Pressure for Lump Observation System

E-HAPLOS: Electrical Impedance Human-guided As...

Cancer Biology
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librarian
150 views
Modelling phenotypic plasticity in cancer invasion and metastasis: from microscopic interactions to macroscopic dynamics

Modelling phenotypic plasticity in cancer inva...

Cancer Biology
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DIMITRIOS KATSAOUNIS
147 views
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