Pharmacology and Toxicology

Rank-Resolved Multi-Engine Docking and Optuna-Optimized Re-Ranking with ProDock for Virtual Screening

Rank-Resolved Multi-Engine Docking and Optuna-...

Pharmacology and Toxicology
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Lai Hoang Son Le
54 views
A non-invasive method of air pollutant exposure in an avian model of development

A non-invasive method of air pollutant exposur...

Pharmacology and Toxicology
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librarian
50 views
An Insectified Caco-2 Cell-Based assay to monitor pesticide Transport Processes and Pharmacokinetics

An Insectified Caco-2 Cell-Based assay to moni...

Pharmacology and Toxicology
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Kassiani Skouloudaki
55 views
Estimating Cardiac 5-HT2B Safety Margins for Repeated Low-Dose Psilocybin Using an Exposure-Response Model

Estimating Cardiac 5-HT2B Safety Margins for R...

Pharmacology and Toxicology
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librarian
44 views
Dronedarone hydrochloride reverses obesity-related metabolic syndrome while preserving skeletal muscle mass

Dronedarone hydrochloride reverses obesity-rel...

Pharmacology and Toxicology
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librarian
43 views
GEM-GPT Enables Personalized Cell Type-Resolved Therapeutic Design for Systems Pharmacology

GEM-GPT Enables Personalized Cell Type-Resolve...

Pharmacology and Toxicology
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librarian
40 views
Endocannabinoid ligands (CBD, Δ9THC, and Terpenes) inhibit excitability of mouse dorsal root ganglion neurons and exhibit synergistic inhibitory effects

Endocannabinoid ligands (CBD, Δ9THC, and Terpe...

Pharmacology and Toxicology
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librarian
43 views
Endothelial β3-Adrenergic Receptor activation prevents pulmonary hypertension

Endothelial β3-Adrenergic Receptor activation ...

Pharmacology and Toxicology
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Eduardo Oliver
46 views
Patolakaturohiniyadi Kashayam, exerts anti-steatotic and anti-obesogenic effects via coordinated regulation of lipid metabolism, inflammation, and incretin signalling.

Patolakaturohiniyadi Kashayam, exerts anti-ste...

Pharmacology and Toxicology
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Sania Kouser
57 views
Species-dependent clearance of alternariol monomethyl ether, tenuazonic acid and altertoxin II in rat and human primary hepatocytes

Species-dependent clearance of alternariol mon...

Pharmacology and Toxicology
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Ludovic Lehegarat
56 views
Human-Relevant Lead Exposure During Differentiation Alters the Transcriptomic Profile of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Human-Relevant Lead Exposure During Differenti...

Pharmacology and Toxicology
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librarian
54 views
An aptamer targeting TfR1 enhances ASO delivery to muscle tissue

An aptamer targeting TfR1 enhances ASO deliver...

Pharmacology and Toxicology
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librarian
53 views
Binding to Albumin and Off-Target Toxicity Confound the Use of LRRC8/VRAC Channel Blockers in Cell Physiology Assays

Binding to Albumin and Off-Target Toxicity Con...

Pharmacology and Toxicology
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Alexander Mongin
54 views
Multiscale learning and topological analysis across complex postures enable robust nematode size quantification in pharmacological assays

Multiscale learning and topological analysis a...

Pharmacology and Toxicology
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librarian
57 views
Perinatal exposure to individual and a metal mixture induces persistent and sex-specific alterations to the cardiac transcriptome of offspring

Perinatal exposure to individual and a metal m...

Pharmacology and Toxicology
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librarian
47 views
Phosphocitrate Is Superior to Pyrophosphate in Preventing Soft Connective Tissue Calcification in a Mouse Model of Pseudoxanthoma Elasticum

Phosphocitrate Is Superior to Pyrophosphate in...

Pharmacology and Toxicology
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Koen van de Wetering
54 views
The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation

The Nematicide Tioxazafen Disrupts Proteasome ...

Pharmacology and Toxicology
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Peter Roy
47 views
Modulation of the agonist and antagonist activity of peptidic FPR1 ligands through N-terminal modifications: A structural and functional analysis

Modulation of the agonist and antagonist activ...

Pharmacology and Toxicology
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librarian
50 views
Increases in serum corticosterone level and diuresis induced by the selective kappa opioid receptor (KOR) agonist U50,488H are unaffected by KOR phosphorylation

Increases in serum corticosterone level and di...

Pharmacology and Toxicology
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librarian
57 views
Multi-Modal Toxicological Evaluation of NiO nanoparticles and ionic nickel in a Human Lung-Cardiac Co-Culture System

Multi-Modal Toxicological Evaluation of NiO na...

Pharmacology and Toxicology
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librarian
54 views
From exact gradients to exact standard errors: third-order sensitivity equations for the FOCE and FOCEI population likelihood

From exact gradients to exact standard errors:...

Pharmacology and Toxicology
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librarian
61 views
Effect of Immunosuppressive Drugs on Glucose-Stimulated Insulin Secretion: Concentration-Response Studies in Dynamic Perifusion Assays

Effect of Immunosuppressive Drugs on Glucose-S...

Pharmacology and Toxicology
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librarian
61 views
Allosteric modulation of β1 integrin through the hybrid domain reverses articular cartilage injury and functional impairment in a murine model of inflammatory arthritis

Allosteric modulation of β1 integrin through t...

Pharmacology and Toxicology
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librarian
68 views
Comprehensive dissection of GPCR signaling using a NanoBiT-based platform

Comprehensive dissection of GPCR signaling usi...

Pharmacology and Toxicology
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librarian
59 views
In vitro EAS-mediated activity of Alternaria toxins

In vitro EAS-mediated activity of Alternaria t...

Pharmacology and Toxicology
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librarian
61 views
AlfaDAX-Derived ActRIIA/B Antibody with Semaglutide Enhances Fat Loss and Improves Weight-Loss Quality in DIO Mice

AlfaDAX-Derived ActRIIA/B Antibody with Semagl...

Pharmacology and Toxicology
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Kingsley Leung
57 views
Hazard characterization of Alternaria toxins - filling data gaps on in vitro genotoxicity.

Hazard characterization of Alternaria toxins -...

Pharmacology and Toxicology
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Anne-Cathrin Behr
54 views
Netrin-1 inhibition does not attenuate cancer-induced bone pain in three translational models

Netrin-1 inhibition does not attenuate cancer-...

Pharmacology and Toxicology
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librarian
58 views
The D2-mdx mouse as a preclinical model for Duchenne muscular dystrophy: a natural history study across two independent sites

The D2-mdx mouse as a preclinical model for Du...

Pharmacology and Toxicology
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librarian
62 views
Cytotoxicity of Pelargonic Acid and Its Commercial Formulation Roundup NL (Glyphosate-Free Roundup)

Cytotoxicity of Pelargonic Acid and Its Commer...

Pharmacology and Toxicology
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Michael Antoniou
69 views
Voclosporin Preserves Mitochondrial Function Compared With Cyclosporine A in Perfused Human Proximal Tubule Microphysiological Systems

Voclosporin Preserves Mitochondrial Function C...

Pharmacology and Toxicology
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Edward Kelly
83 views
Mechanistic characterization of tenuazonic acid-induced cellular stress responses in human esophageal KYSE-510 cells

Mechanistic characterization of tenuazonic aci...

Pharmacology and Toxicology
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Dino Grgic
57 views
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