Pharmacology and Toxicology

TREM2 Hit Discovery Using TRIC Technology: A Proof-of-Concept High-Throughput Screening Approach

TREM2 Hit Discovery Using TRIC Technology: A P...

Pharmacology and Toxicology
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librarian
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Evolving resistance patterns in Tetranychus urticae and Bemisia tabaci in Greece

Evolving resistance patterns in Tetranychus ur...

Pharmacology and Toxicology
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librarian
11 views
Determination of chemical partitioning in vehicles using a skin surrogate for dermal absorption model refinement.

Determination of chemical partitioning in vehi...

Pharmacology and Toxicology
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librarian
26 views
Stochastic gates for covariate selection in population pharmacokinetics modelling

Stochastic gates for covariate selection in po...

Pharmacology and Toxicology
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librarian
23 views
Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28

Rules of engagement: determinants of chemokine...

Pharmacology and Toxicology
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librarian
25 views
Oxidative stress and vacuolar variants influence paraquat response in Saccharomyces cerevisiae of different genetic variants

Oxidative stress and vacuolar variants influen...

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Andres Klein
25 views
IQM-22110 as a selective KV4.3/KChIP3 modulator. Molecular determinants of the KChIP3 binding site

IQM-22110 as a selective KV4.3/KChIP3 modulato...

Pharmacology and Toxicology
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librarian
30 views
Non-Equilibrium Snapshots of Ligand Efficacy at the μ-Opioid Receptor

Non-Equilibrium Snapshots of Ligand Efficacy a...

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Georgios Skiniotis
29 views
Validation of a high-throughput screening assay for the characterization of cryoprotective agent toxicity

Validation of a high-throughput screening assa...

Pharmacology and Toxicology
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Rebecca Sandlin
25 views
Discovery and Development of DC-174 as a Novel Oral Snakebite Treatment

Discovery and Development of DC-174 as a Novel...

Pharmacology and Toxicology
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librarian
31 views
In-dwelling microfluidic device for precise and reliable intranasal drug delivery during freely-moving behavior

In-dwelling microfluidic device for precise an...

Pharmacology and Toxicology
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librarian
27 views
TRPV4 activation enhances LPS-induced IL10 production to suppress excessive microglial activation

TRPV4 activation enhances LPS-induced IL10 pro...

Pharmacology and Toxicology
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librarian
30 views
Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

Mechanism of SK2 channel gating and its modula...

Pharmacology and Toxicology
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librarian
28 views
Neurotoxicity of Propylene Glycol Butyl Ether: Multiomic Evidence from Human BrainSpheres

Neurotoxicity of Propylene Glycol Butyl Ether:...

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Marie-Gabrielle Zurich
27 views
Endothelial c-IAP2 Loss Amplifies P2X7 Receptor-Driven Inflammation and Worsens Infection-Associated Pulmonary Hypertension

Endothelial c-IAP2 Loss Amplifies P2X7 Recepto...

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Suellen Oliveira
27 views
Identification of antibody-drug conjugate payloads which are substrates of ATP-binding cassette drug efflux transporters

Identification of antibody-drug conjugate payl...

Pharmacology and Toxicology
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Matthew Hall
29 views
Identification of new KCNT1-epilepsy drugs by in silico, cell and Drosophila modelling.

Identification of new KCNT1-epilepsy drugs by ...

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Jonathan Lippiat
41 views
Intranasal Dantrolene Nanoparticles for Treatment of Amyotrophic Lateral Sclerosis as a Disease-Modifying Drug

Intranasal Dantrolene Nanoparticles for Treatm...

Pharmacology and Toxicology
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librarian
27 views
Bisdemethoxycurcumin mitigates Alzheimer disease pathology through autophagy-mediated reduction of senescence and amyloid beta

Bisdemethoxycurcumin mitigates Alzheimer disea...

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Ajay Kumar
33 views
Evaluating the efficacy of LUMPY-NIL herbal powder, dermal Spray and dermal ointment in treating Lumpy Skin Disease (LSD) in Bovines

Evaluating the efficacy of LUMPY-NIL herbal po...

Pharmacology and Toxicology
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librarian
30 views
RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription

RAC1 Regulates Shh-Medulloblastoma Growth via ...

Pharmacology and Toxicology
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librarian
27 views
Alcohol Disrupts Neural Differentiation Through Endoplasmic Reticulum Stress and PERK Pathway Activation

Alcohol Disrupts Neural Differentiation Throug...

Pharmacology and Toxicology
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librarian
32 views
Mitragynine and 7-Hydroxymitragynine: Bidirectional Effects on Breathing in Rats

Mitragynine and 7-Hydroxymitragynine: Bidirect...

Pharmacology and Toxicology
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Samuel Obeng
31 views
Differential responses of murine embryonic stem cells (mESC) and their endothelial progeny to doxorubicin and pharmacological inhibitors of DNA repair and DNA damage response

Differential responses of murine embryonic ste...

Pharmacology and Toxicology
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librarian
31 views
The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels

The sodium/glucose cotransporter 2 inhibitor e...

Pharmacology and Toxicology
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Karlheinz Hilber
37 views
CHI3L1-Targeted Small Molecules as Glioblastoma Therapies: Virtual Screening-Based Discovery, Biophysical Validation, Pharmacokinetic Profiling, and Evaluation in Glioblastoma Spheroids

CHI3L1-Targeted Small Molecules as Glioblastom...

Pharmacology and Toxicology
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librarian
37 views
Promising protocol for in vivo experiments with betulin

Promising protocol for in vivo experiments wit...

Pharmacology and Toxicology
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librarian
37 views
Discovery and structure-activity relationship analysis of 2-Pyridyl Thienopyrimidine derivatives as promising therapeutic candidates for the treatment of Buruli ulcer

Discovery and structure-activity relationship ...

Pharmacology and Toxicology
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Fabrice Boyom
38 views
Theanine boosts frontal theta and hippocampal beta and gamma oscillations for familiarity in object recognition

Theanine boosts frontal theta and hippocampal ...

Pharmacology and Toxicology
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Nobuyoshi Matsumoto
35 views
High-resolution imaging reveals a cascade of interconnected cellular bioeffects differentiating the long-term fates of sonoporated cells

High-resolution imaging reveals a cascade of i...

Pharmacology and Toxicology
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Pranesh Padmanabhan
33 views
Screening for cryoprotective agent toxicity and toxicity reduction in mixtures at subambient temperatures

Screening for cryoprotective agent toxicity an...

Pharmacology and Toxicology
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librarian
33 views
A Mechanism Based Pharmacokinetic/Pharmacodynamic Analysis of Polymyxin B-Based Combination Therapy Against Carbapenem-Resistant Klebsiella pneumoniae Isolates with Diverse Phenotypic and Genotypic Resistance Mechanisms

A Mechanism Based Pharmacokinetic/Pharmacodyna...

Pharmacology and Toxicology
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librarian
34 views
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