Pharmacology and Toxicology

Integrated evaluation of immune system perturbation using structural, functional and cellular immunotoxicity endpoints in rats

Integrated evaluation of immune system perturb...

Pharmacology and Toxicology
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Vinay Lomash
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Transporter-Mediated Uptake of Microcystin-LR in Human Trophoblasts: Regulation By Oxygen Concentration and Cell Fusion

Transporter-Mediated Uptake of Microcystin-LR ...

Pharmacology and Toxicology
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librarian
2 views
In vitro investigation and evaluation of the antidiabetic potential of the ethanolic extract of Asparagus racemosus using starch digestion, glucose diffusion, glucose uptake, and DPPH assays

In vitro investigation and evaluation of the a...

Pharmacology and Toxicology
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Md. Sifat Rahman
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Microencapsulated Vaccinium floribundum Kunth extract promotes angiogenesis and attenuates inflammation in in vitro and in vivo models.

Microencapsulated Vaccinium floribundum Kunth ...

Pharmacology and Toxicology
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Giulia Biondolillo
3 views
Investigating the nicotinic receptor EAT-2 as a novel target to mitigate plant parasitic nematode infections

Investigating the nicotinic receptor EAT-2 as ...

Pharmacology and Toxicology
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Henry Nvenankeng
4 views
Effects of polystyrene and polylactide nanoparticles on macrophages under a repeated exposure mode

Effects of polystyrene and polylactide nanopar...

Pharmacology and Toxicology
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librarian
8 views
Anti-oxidant and anti-inflammatory Effects of Aerosolised microalgal-derived extracellular vesicles in Bronchial Epithelial-Macrophage Co-cultures at the Air-Liquid Interface

Anti-oxidant and anti-inflammatory Effects of ...

Pharmacology and Toxicology
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librarian
5 views
BODIPY-Tagged β-Lactams as Selective Quenched Activity-Based Probes to Target Human Neutrophil Elastase

BODIPY-Tagged β-Lactams as Selective Quenched ...

Pharmacology and Toxicology
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librarian
5 views
Molecular Determinants Governing the Antitubercular Activity of Griselimycin

Molecular Determinants Governing the Antituber...

Pharmacology and Toxicology
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Andrew Spira
5 views
Efficacy of SGLT2 Inhibitors in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis of Preclinical Studies

Efficacy of SGLT2 Inhibitors in Pulmonary Arte...

Pharmacology and Toxicology
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librarian
10 views
Anti-inflammatory and pro-proliferative effects of fasudil in human trisomy 21 neural progenitor cells

Anti-inflammatory and pro-proliferative effect...

Pharmacology and Toxicology
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Diana Bianchi
11 views
Nanoparticle-in-Microparticle Oral Delivery System Based on Drug-Loaded Polymeric Micelles

Nanoparticle-in-Microparticle Oral Delivery Sy...

Pharmacology and Toxicology
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librarian
10 views
Patchouli alcohol suppresses gastric cancer growth and immune evasion via inhibition of the NF-κB/PD-L1 axis

Patchouli alcohol suppresses gastric cancer gr...

Pharmacology and Toxicology
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Kun Hou
10 views
Voltage-Gated Sodium Channel Modulation Differentially Alters ON and OFF Bipolar Cell Contributions to the Rat ERG

Voltage-Gated Sodium Channel Modulation Differ...

Pharmacology and Toxicology
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librarian
9 views
Integrated Skin Sensitization Assessment Using Consensus Modelling and Tiered New Approach Methodology: A SaferSkin Case Study

Integrated Skin Sensitization Assessment Using...

Pharmacology and Toxicology
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librarian
10 views
A Novel Hollow Fiber Infection Model (HFIM) for Antiviral PK/PD studies of CMV infection.

A Novel Hollow Fiber Infection Model (HFIM) fo...

Pharmacology and Toxicology
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librarian
14 views
Cancer-derived Extracellular Vesicles for Targeted Delivery of EGFRvIII siRNA to Glioblastoma, Comparison of siRNA Loading Methods and Efficiency

Cancer-derived Extracellular Vesicles for Targ...

Pharmacology and Toxicology
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librarian
447 views
Red yeast rice-derived MKA ameliorates cardiac hypertrophy in hypertensive rats by inhibiting ERK1/2/c-Fos pathway

Red yeast rice-derived MKA ameliorates cardiac...

Pharmacology and Toxicology
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Xiaoqiu Tan
17 views
Introduction to Single-cell Physiologically-Based Pharmacokinetic (scPBPK) Models

Introduction to Single-cell Physiologically-Ba...

Pharmacology and Toxicology
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librarian
23 views
Discovery of the first small-molecule extracellular inhibitor of KCa3.1

Discovery of the first small-molecule extracel...

Pharmacology and Toxicology
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librarian
18 views
Paralysis Efficiency (ED50) Scales Linearly with Lethality (LD50) in Spider Venoms

Paralysis Efficiency (ED50) Scales Linearly wi...

Pharmacology and Toxicology
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librarian
22 views
Discovery of Novel Ligands for Cryptococcus neoformans

Discovery of Novel Ligands for Cryptococcus ne...

Pharmacology and Toxicology
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Fernando Cagide
27 views
RGS6 regulates Kappa Opioid Receptor-mediated antinociceptivebehaviors

RGS6 regulates Kappa Opioid Receptor-mediated ...

Pharmacology and Toxicology
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Laurie Sutton
22 views
A spoonful of what helps the medicine go down? Improving the reliability of voluntary ingestion for oral dosing in rats and mice

A spoonful of what helps the medicine go down?...

Pharmacology and Toxicology
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librarian
20 views
Partial Differential Equation (PDE) Based Spatial Pharmacometrics in NONMEM: Method of Lines (MOL) Implementation With AI-Assisted Model Development

Partial Differential Equation (PDE) Based Spat...

Pharmacology and Toxicology
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librarian
21 views
Beyond Student's t: A Systematic Exploration of Heavy-Tailed Residual Densities for Outlier Handling in Population PK Modeling

Beyond Student's t: A Systematic Exploration o...

Pharmacology and Toxicology
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librarian
22 views
Delay Differential Equation (DDE) Modeling of CAR-T Cellular Kinetics: Application to BCMA-Targeted (Ide-cel, Orva-cel) and CD19-Targeted (Liso-cel) Therapies

Delay Differential Equation (DDE) Modeling of ...

Pharmacology and Toxicology
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Yan Li
26 views
Matrix metalloproteinases proteolyze RAB proteins and contribute to cisplatin-induced ototoxicity

Matrix metalloproteinases proteolyze RAB prote...

Pharmacology and Toxicology
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librarian
24 views
Acute Toxicological Profile of Pharmaceutical-Grade Nicotinamide Riboside: A Route-Dependent Assessment Across Intravenous, Intramuscular, and Subcutaneous Administration

Acute Toxicological Profile of Pharmaceutical-...

Pharmacology and Toxicology
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Jun Kwon
26 views
Tetracycline-Regulated Inducible CB2 Expression in AtT20 Cells: A Functional Assay for Quantifying Ligand Efficacy

Tetracycline-Regulated Inducible CB2 Expressio...

Pharmacology and Toxicology
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Mark Connor
29 views
vToxiNet: a biologically constrained deep learning framework for interpretable prediction of drug-induced hepatotoxicity

vToxiNet: a biologically constrained deep lear...

Pharmacology and Toxicology
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Hao Zhu
25 views
Short-Term Performance Assay Identifies Functional Benefits and Early Toxicity of Longevity Interventions in Mice

Short-Term Performance Assay Identifies Functi...

Pharmacology and Toxicology
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Alberto Parras
57 views
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