Pharmacology and Toxicology

Protein Age Bias in Target Degradation by PROTACs

Protein Age Bias in Target Degradation by PROTACs

Pharmacology and Toxicology
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librarian
4 views
Phosphoproteomics in Daphnia magna as a tool to decipher molecular mechanisms in ecotoxicological studies

Phosphoproteomics in Daphnia magna as a tool t...

Pharmacology and Toxicology
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Thomas Fröhlich
4 views
Intraventricular infusion to circumvent the blood-brain barrier to gemcitabine.

Intraventricular infusion to circumvent the bl...

Pharmacology and Toxicology
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Bruno CHAUFFERT
6 views
TRPA1 channel activation by synthetic lipid nanoparticles

TRPA1 channel activation by synthetic lipid na...

Pharmacology and Toxicology
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librarian
9 views
Extreme Hydrophobicity of Cytotoxic Drugs Enables Design of Next Generation Antibody-Drug Conjugates Nanotherapeutics

Extreme Hydrophobicity of Cytotoxic Drugs Enab...

Pharmacology and Toxicology
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librarian
10 views
Inhibition of oogenic JNK preserves fertility and ovarian hormones during DNA-damaging cancer therapy

Inhibition of oogenic JNK preserves fertility ...

Pharmacology and Toxicology
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librarian
20 views
Lysophosphatidic Acid (LPA) Salivary Species Detection and Whole-mount LPA Receptor Localization in Mouse Salivary Gland

Lysophosphatidic Acid (LPA) Salivary Species D...

Pharmacology and Toxicology
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librarian
23 views
Selective targeting of the oligodendroglial GPR17 receptor improves myelin integrity and motor function in female SOD1G93A mice

Selective targeting of the oligodendroglial GP...

Pharmacology and Toxicology
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librarian
15 views
Otenabant is a Selective Antagonist of Human PIEZO1

Otenabant is a Selective Antagonist of Human P...

Pharmacology and Toxicology
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librarian
15 views
Phytochemical profiling, antioxidant capacity, and in vivo safety assessment of Warrigal spinach (Tetragonia tetragonioides) and Kensington Pride mango (Mangifera indica) extracts using Zebrafish larvae

Phytochemical profiling, antioxidant capacity,...

Pharmacology and Toxicology
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librarian
14 views
Multidimensional Mechanistic Study of Panax Notoginseng Saponins in the Treatment of Alcohol-Induced Osteonecrosis of the Femoral Head: Integrating Network Pharmacology, Molecular Dynamics Simulation and In Vivo Validation

Multidimensional Mechanistic Study of Panax No...

Pharmacology and Toxicology
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Jian Mo
21 views
Isoquercetin treatment of mouse sickled red blood cells shows a discernible deformability and sickling phenotype

Isoquercetin treatment of mouse sickled red bl...

Pharmacology and Toxicology
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Moua Yang
18 views
Triptans reprogram Schwann cells to drive medication-overuse headache via β-glycan/TGF-β3 signaling

Triptans reprogram Schwann cells to drive medi...

Pharmacology and Toxicology
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Alberto Magi
17 views
Organophosphorus pesticide and nerve agent surrogate metabolism by human CYP3A4

Organophosphorus pesticide and nerve agent sur...

Pharmacology and Toxicology
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Craig McElroy
20 views
Unexpected antidepressant-like effects of temozolomide in a mixed sex-cohort of adult rats: role of hippocampal FADD protein

Unexpected antidepressant-like effects of temo...

Pharmacology and Toxicology
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librarian
22 views
PM2.5 toxin benzopyrene induces life-limiting inflammation and oxidative stress in the airway by up-regulation of TRPC6 and inactivation of β2AR/CFTR signaling

PM2.5 toxin benzopyrene induces life-limiting ...

Pharmacology and Toxicology
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Harvey Pollard
28 views
Generation of High-Affinity Anti-GIPR Antagonist Antibodies with Sustained and Non-rebound Weight Loss in DIO Mice by AlfaBodY

Generation of High-Affinity Anti-GIPR Antagoni...

Pharmacology and Toxicology
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librarian
20 views
Towards Bayesian-based quantitative adverse outcome pathways using in vitro data from open literature and continuous variables: a case example for liver fibrosis.

Towards Bayesian-based quantitative adverse ou...

Pharmacology and Toxicology
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Lola Bajard
29 views
Glucose and fructose differently mediate alcohol cocktail drinking in female and male rats: interaction of glucose and alcohol on post-ingestive behavior

Glucose and fructose differently mediate alcoh...

Pharmacology and Toxicology
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Ken Wakabayashi
42 views
Kinetics of cortisol and cortisone binding to corticosteroid binding globulin and albumin in vivo

Kinetics of cortisol and cortisone binding to ...

Pharmacology and Toxicology
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librarian
33 views
A Nonsteroidal Reversal Agent Inhibits Allopregnanolone Modulation of α1β3δ GABAA Receptors

A Nonsteroidal Reversal Agent Inhibits Allopre...

Pharmacology and Toxicology
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Keith Miller
36 views
Slow Dissociation of Nitazenes from the μ-Opioid Receptor Underlies the Challenge of Overdose Reversal

Slow Dissociation of Nitazenes from the μ-Opio...

Pharmacology and Toxicology
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librarian
33 views
N-3 Polyunsaturated Fatty Acids Ameliorate Post-infarction Cardiac Dysfunction Through Modulation Of Adiponectin-Ceramide Metabolism

N-3 Polyunsaturated Fatty Acids Ameliorate Pos...

Pharmacology and Toxicology
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Xiaofei Guo
28 views
Increased utrophin expression in healthy and DMD patient derived myoblasts in response to ERK1/2 and EZH2 inhibitor treatment

Increased utrophin expression in healthy and D...

Pharmacology and Toxicology
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Hannah Gleneadie
33 views
Three nitrogen atoms turn old kinase inhibitors into new targetable remedy

Three nitrogen atoms turn old kinase inhibitor...

Pharmacology and Toxicology
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librarian
34 views
Using Patient iPSC-derived Retinal Pigment Epithelial Cells to Evaluate Differential Susceptibility to MEK Inhibitor-Associated Retinopathy

Using Patient iPSC-derived Retinal Pigment Epi...

Pharmacology and Toxicology
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librarian
27 views
Impact of Sex on Heroin Intravenous Self-Administration by Heterogeneous Stock Rats

Impact of Sex on Heroin Intravenous Self-Admin...

Pharmacology and Toxicology
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librarian
38 views
Influence of different pharmaceuticals on the germination and early development of two leafy vegetable species

Influence of different pharmaceuticals on the ...

Pharmacology and Toxicology
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librarian
28 views
Pinus sp. leaf extracts exert antileishmanial effects against Leishmania donovani by targeting trypanothione reductase

Pinus sp. leaf extracts exert antileishmanial ...

Pharmacology and Toxicology
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librarian
38 views
PROTAC internalization and target degradation require clathrin-mediatedendocytosis

PROTAC internalization and target degradation ...

Pharmacology and Toxicology
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Hong-Yu Li
44 views
Morphological and Functional Effects of Cytoskeletal and Ion-Channel Agents on the Protoscolex of Echinococcus granulosus sensu lato

Morphological and Functional Effects of Cytosk...

Pharmacology and Toxicology
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librarian
36 views
Simian Immunodeficiency Virus and Antiretroviral Therapy Impact Rhesus Macaque Brain Lipid Distribution

Simian Immunodeficiency Virus and Antiretrovir...

Pharmacology and Toxicology
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librarian
40 views
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