Pharmacology and Toxicology

TREM2 Hit Discovery Using TRIC Technology: A Proof-of-Concept High-Throughput Screening Approach
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librarian
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Evolving resistance patterns in Tetranychus urticae and Bemisia tabaci in Greece
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librarian
11 views
Determination of chemical partitioning in vehicles using a skin surrogate for dermal absorption model refinement.
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librarian
26 views
Stochastic gates for covariate selection in population pharmacokinetics modelling
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librarian
23 views
Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28
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librarian
25 views
Oxidative stress and vacuolar variants influence paraquat response in Saccharomyces cerevisiae of different genetic variants
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Andres Klein
25 views
IQM-22110 as a selective KV4.3/KChIP3 modulator. Molecular determinants of the KChIP3 binding site
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librarian
30 views
Non-Equilibrium Snapshots of Ligand Efficacy at the μ-Opioid Receptor
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Georgios Skiniotis
29 views
Validation of a high-throughput screening assay for the characterization of cryoprotective agent toxicity
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Rebecca Sandlin
25 views
Discovery and Development of DC-174 as a Novel Oral Snakebite Treatment
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librarian
31 views
In-dwelling microfluidic device for precise and reliable intranasal drug delivery during freely-moving behavior
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librarian
27 views
TRPV4 activation enhances LPS-induced IL10 production to suppress excessive microglial activation
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librarian
30 views
Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules
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librarian
28 views
Neurotoxicity of Propylene Glycol Butyl Ether: Multiomic Evidence from Human BrainSpheres
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Marie-Gabrielle Zurich
27 views
Endothelial c-IAP2 Loss Amplifies P2X7 Receptor-Driven Inflammation and Worsens Infection-Associated Pulmonary Hypertension
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Suellen Oliveira
27 views
Identification of antibody-drug conjugate payloads which are substrates of ATP-binding cassette drug efflux transporters
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Matthew Hall
29 views
Identification of new KCNT1-epilepsy drugs by in silico, cell and Drosophila modelling.
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Jonathan Lippiat
41 views
Intranasal Dantrolene Nanoparticles for Treatment of Amyotrophic Lateral Sclerosis as a Disease-Modifying Drug
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librarian
27 views
Bisdemethoxycurcumin mitigates Alzheimer disease pathology through autophagy-mediated reduction of senescence and amyloid beta
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Ajay Kumar
33 views
Evaluating the efficacy of LUMPY-NIL herbal powder, dermal Spray and dermal ointment in treating Lumpy Skin Disease (LSD) in Bovines
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librarian
30 views
RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription
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librarian
27 views
Alcohol Disrupts Neural Differentiation Through Endoplasmic Reticulum Stress and PERK Pathway Activation
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librarian
32 views
Mitragynine and 7-Hydroxymitragynine: Bidirectional Effects on Breathing in Rats
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Samuel Obeng
31 views
Differential responses of murine embryonic stem cells (mESC) and their endothelial progeny to doxorubicin and pharmacological inhibitors of DNA repair and DNA damage response
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librarian
31 views
The sodium/glucose cotransporter 2 inhibitor empagliflozin is a pharmacological chaperone of cardiac Nav1.5 channels
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Karlheinz Hilber
37 views
CHI3L1-Targeted Small Molecules as Glioblastoma Therapies: Virtual Screening-Based Discovery, Biophysical Validation, Pharmacokinetic Profiling, and Evaluation in Glioblastoma Spheroids
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librarian
37 views
Promising protocol for in vivo experiments with betulin
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librarian
37 views
Discovery and structure-activity relationship analysis of 2-Pyridyl Thienopyrimidine derivatives as promising therapeutic candidates for the treatment of Buruli ulcer
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Fabrice Boyom
38 views
Theanine boosts frontal theta and hippocampal beta and gamma oscillations for familiarity in object recognition
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Nobuyoshi Matsumoto
35 views
High-resolution imaging reveals a cascade of interconnected cellular bioeffects differentiating the long-term fates of sonoporated cells
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Pranesh Padmanabhan
33 views
Screening for cryoprotective agent toxicity and toxicity reduction in mixtures at subambient temperatures
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librarian
33 views
A Mechanism Based Pharmacokinetic/Pharmacodynamic Analysis of Polymyxin B-Based Combination Therapy Against Carbapenem-Resistant Klebsiella pneumoniae Isolates with Diverse Phenotypic and Genotypic Resistance Mechanisms
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librarian
34 views