Systems Biology

Network topology dictates sequential drug efficacy through bistability-mediated state switching

Network topology dictates sequential drug effi...

Systems Biology
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librarian
3 views
The Limits of Cross-Species WGCNA: Library Imbalance and Signal Dilution Constrain Effector Gene Recovery in Dual-Organism RNA-seq

The Limits of Cross-Species WGCNA: Library Imb...

Systems Biology
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librarian
4 views
Systems modeling identifies phenotype-determining signaling pathways controlled by phosphatase PTPRJ in diverse receptor tyrosine kinase activation settings

Systems modeling identifies phenotype-determin...

Systems Biology
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librarian
6 views
A Scalable Sign-Aware Multi-Omics Knowledge Graph Foundation Model for Mechanistic Drug Action and Clinical Response Predictions

A Scalable Sign-Aware Multi-Omics Knowledge Gr...

Systems Biology
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Lei Xie
4 views
A Comprehensive Mathematical Model of Avidity in Cytokine Signaling

A Comprehensive Mathematical Model of Avidity ...

Systems Biology
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librarian
7 views
A low-dimensional transcriptional code enables decoding of BMP/TGFβ signaling from single-cell transcriptomes

A low-dimensional transcriptional code enables...

Systems Biology
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librarian
20 views
A transcriptional patient map of systemic lupus erythematosus reveals disease-related multicellular immune programs conserved between blood and kidney

A transcriptional patient map of systemic lupu...

Systems Biology
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librarian
17 views
A unified framework for causal gene regulatory network inference grounded in orthogonal molecular evidence

A unified framework for causal gene regulatory...

Systems Biology
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B. Franklin Pugh
17 views
Bidirectional network hubs: NT-genes as optimal targets for partial cancer reversal

Bidirectional network hubs: NT-genes as optima...

Systems Biology
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Augusto Gonzalez
18 views
DrugPTM-Bench: A Large-Scale Dataset for Predictive Modeling of Drug-Induced Cell Type-Specific Protein Post-Translational Modifications

DrugPTM-Bench: A Large-Scale Dataset for Predi...

Systems Biology
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Amitesh Badkul
21 views
Aging Rhesus Macaque show tissue and sex-specific balance of drifting and coordinated miRNA programs

Aging Rhesus Macaque show tissue and sex-speci...

Systems Biology
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librarian
17 views
A Minimal Regulatory Spatial Model for Emergent Multicellular Organization in Dissipative Environments

A Minimal Regulatory Spatial Model for Emergen...

Systems Biology
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librarian
19 views
Proteome-aware organ proxy aging clocks

Proteome-aware organ proxy aging clocks

Systems Biology
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librarian
29 views
Data-driven lifespan transitions: cortical morphometry and intrinsic differences across network scales

Data-driven lifespan transitions: cortical mor...

Systems Biology
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Rose Cuthbertson
22 views
Defining Cell Types through Maximally Informative Biological Atlases

Defining Cell Types through Maximally Informat...

Systems Biology
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Roy Wollman
22 views
Impact of variability in cell generation times on cell-to-cell variability of protein concentrations

Impact of variability in cell generation times...

Systems Biology
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librarian
20 views
HyperMap: An Efficient Framework for Transferring Perturbation Responses Across Diverse Biological Contexts

HyperMap: An Efficient Framework for Transferr...

Systems Biology
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librarian
23 views
Extreme genome reduction selectively retains modular regulatory architecture in Prochlorococcus MED4: conserved transcriptional modules reveal core physiological regulatory programs

Extreme genome reduction selectively retains m...

Systems Biology
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Pavlo Bohutskyi
28 views
Orchard management alters citrus root and rhizosphere microbiomes with functional consequences for plant performance

Orchard management alters citrus root and rhiz...

Systems Biology
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M. Caroline Roper
34 views
SEC-seq reveals translation-focused metabolic strategies for high IgG productivity in clonal CHO cells

SEC-seq reveals translation-focused metabolic ...

Systems Biology
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librarian
29 views
Serum protein profiling reveals hallmark-level aging trajectories and strain-specific resilience in CB6F1J and C57BL/6J male mice.

Serum protein profiling reveals hallmark-level...

Systems Biology
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librarian
32 views
Mapping kidney trait heritability to individual cells reals disease-specific remodeling of genetic risk architecture

Mapping kidney trait heritability to individua...

Systems Biology
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Huiqian Hu
40 views
Opto-MDMi: a dual-lock optogenetic system for robust activation of endogenous p53

Opto-MDMi: a dual-lock optogenetic system for ...

Systems Biology
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Kazuhiro Aoki
26 views
NovoGlyco: mapping protein glycosylation in prokaryotes

NovoGlyco: mapping protein glycosylation in pr...

Systems Biology
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Dinko Soic
28 views
Targeting HIV at its core: A mathematical model for optimizing Tat Inhibitor-based therapies toward enhanced functional cure strategies

Targeting HIV at its core: A mathematical mode...

Systems Biology
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librarian
34 views
iCNG99: a validated genome-scale metabolic model of Cryptococcus neoformans strain H99

iCNG99: a validated genome-scale metabolic mod...

Systems Biology
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librarian
38 views
Equation-Based Integration of Flux Balance Analysis with Diffusion for Spatio-Temporal Simulation of Microbial Communities

Equation-Based Integration of Flux Balance Ana...

Systems Biology
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librarian
36 views
Modeling and dissecting bidirectional feedback in gene-metabolite systems using the CausalFlux method

Modeling and dissecting bidirectional feedback...

Systems Biology
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librarian
32 views
Pushing the limits of SCP: bacSCP, a proof-of-concept study to investigate heterogeneity of bacteria by single cell proteomics.

Pushing the limits of SCP: bacSCP, a proof-of-...

Systems Biology
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librarian
32 views
Antimony 3: Extending human-readable model definitions for SBML Level 3 Core and Packages

Antimony 3: Extending human-readable model def...

Systems Biology
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librarian
35 views
Cell-Type-Resolved Pseudobulk Classification Across Independent Cohorts Identifies Microglial PTPRG as a Transcriptional Hub in Alzheimer's Disease

Cell-Type-Resolved Pseudobulk Classification A...

Systems Biology
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Annikka Polster
33 views
Rhythmic gene expression and behavioral plasticity in harvester and carpenter ants

Rhythmic gene expression and behavioral plasti...

Systems Biology
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Biplabendu Das
37 views
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